2013 Fiscal Year Final Research Report
Molecular mechanisms and evolutionary origin of the robustness in vertebrate development
| Project/Area Number |
23570256
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Nagahama Institute of Bio-Science and Technology (2013)
Nara Institute of Science and Technology (2011-2012) |
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Principal Investigator |
OGINO HAJIME 長浜バイオ大学, バイオサイエンス学部, 教授 (10273856)
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| Co-Investigator(Renkei-kenkyūsha) |
OCHI Haruki 山形大学, 医学部教育研究支援センター, 助教 (00505787)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 発生・分化 / 進化 / ゲノム / 発現制御 / 遺伝子 |
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| Research Abstract |
In this study, we attempted to reveal molecular mechanisms that confer robustness to vertebrate development, and its evolutionary origin, by studying the regulation of paralogs generated by ancient whole genome duplications. In case of Nr2f-paralogs, we found that Nr2f1, Nr2f2, Nr2f5 and Nr2f6, show partially overlapping expression in the eye and brain, and three pairs of enhancers generated by the genome duplication are still conserved between Nr2f1 and Nr2f2. Regarding Pax2 and Pax5 paralogs, an ancestral-type sequence of their expression-compensation enhancers was identified in the cephalochordate amphioxus.
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