2013 Fiscal Year Final Research Report
Gene expression of transcription factors in the central nervous system of primates
| Project/Area Number |
23570282
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical anthropology
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| Research Institution | Kyoto University |
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Principal Investigator |
OISHI Takao 京都大学, 霊長類研究所, 准教授 (40346036)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 大脳皮質 / 小脳 / 大脳基底核 / 海馬 / 発達 / DNAマイクロアレイ |
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| Research Abstract |
Aging brought about increase in expression of immunity-related genes and decrease in expression of mitochondria- and synaptic transmission-related genes in the neocortex and the hippocampus of macaque monkeys. Gene expressions suggest that enhancement of mitochondrial function and remyelination occur in the human brain and deterioration of mitochondrial function and demyelination occur in the macaque brain.
In the macaque neocortex, neocortex-specific gene groups were expressed in addition to gene expressions in common with the hippocampus. There were no genes of transcription factor whose expression was in concordance with the process of myelination or demyelination. Estrogen and related substances may regulate gene expressions of transcription factors, whose expression was in concordance with the degree of myelination.
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[Journal Article] Differential Expression of Secreted Phosphoprotein 1 in the Motor Cortex among Primate Species and during Postnatal Development and Functional Recovery2013
Author(s)
Yamamoto T, Oishi T, Higo N, Murayama S, Sato A, Takashima I, Sugiyama Y, Nishimura Y, Murata Y, Yoshino-Saito K, Isa T, Kojima T
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Journal Title
PLoS One
Volume: 8
Pages: 1-13
DOI
Peer Reviewed
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[Presentation] Gene network analysis of genes differentially expressed between primary motor and prefrontal association cortices of macaque brain2012
Author(s)
T. Kojima, N. Higo, A. Sato, T. Oishi, Y. Nishimura, T. Yamamoto, Y. Murata, K. Yoshino-Saito, H. Onoe, T. Isa
Organizer
Neuroscience 2012
Place of Presentation
New Orleans, USA
Year and Date
2012-10-17
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