2013 Fiscal Year Final Research Report
Starvation stress-responsive transcription factor is involved in the regulation of memory-independent social behavior of mouse
| Project/Area Number |
23580141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
TAKAHASHI YUJI 東京薬科大学, 生命科学部, 教授 (20154875)
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| Co-Investigator(Kenkyū-buntansha) |
MARIKO Umemura 東京薬科大学, 生命科学部, 助教 (30521489)
HARUO Nakano 東京薬科大学, 生命科学部, 助教 (60601870)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ストレス応答 / 転写調節因子 / 自閉症スペクトラム / 嗅球 |
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| Research Abstract |
Activating Transcription Factor 5 (ATF5), starvation-induced stress-responsive transcription factor, is expressed strongly in the subventricular zone and weekly in the wide range of the brain. Olfactory neurons in olfactory epithelium also express ATF5 abundantly. We made ATF5-deficent congenic mice and used them to test behavioral characteristics, including anxiety, perseveration, social contact, working memory and reference memory. ATF5-deficient mice showed hyperactivity, strong anxiety, depressed social activity and strong tendency of perseveration, independent of working and reference memories. These behavioral features indicate that ATF5-deficient mice show autism spectrum-like behavioral abnormality. Histochemical examination of the odorant bulb of ATF5-defficient mice revealed that ATF5 is involved in the neural activity of odorant perception.
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[Journal Article] N-terminal hydrophobic amino acids of ATF5 confer IL-1b-induced stabilization2014
Author(s)
Abe T., Kojima M., Akanuma S., Iwashita H., Yamazaki T., Okuyama R., Ichikawa K., Umemura M., Nakano H., Takahashi S., and Takahashi Y.
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Journal Title
J Biol Chem
Volume: 289
Pages: 3888-3900
DOI
Peer Reviewed
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[Journal Article] A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta2013
Author(s)
Lu J., Zhang S., Nakano H., Simmons D.G., Wang S., Kong S., Wang Q., Shen L., Tu Z., Wang W., Wang B., Wang H., Wang Y., van Es J. H., Clevers H., Leone G., Cross J.C., Wang H.
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Journal Title
PLOS Biol
Volume: 11
Pages: e1001536
DOI
Peer Reviewed
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[Journal Article] Detection of vertebrate-type sterid hormones and their converting activity in the neogastropid, Thais clavigera2012
Author(s)
Goto, Y., Kajiwara, M., Yanagisawa, Y., Hirose, H., Yoshimi, T., Umemura, M., Nakano, H., Takahashi, S., Shida, Y., Iguchi, T., Takahashi, Y., Miura T.
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Journal Title
J. Mol. Studies
Volume: 78
Pages: 197-204
DOI
Peer Reviewed
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[Presentation] Involvement of retinoic acid pathway in tissue regeneration of Thais clavigera2012
Author(s)
Watanabe, H., Itou, T., Nagasawa, K., Kaneko, H., Mizukami, K., Aya Saiga, A., Nakano, H., Umemura, M., Shigeru Takahashi, S., Takahashi, Y.
Organizer
Gordon Research Conference on Environmental Endocrine Disruptors
Place of Presentation
New Hampshire, USA
Year and Date
20120600
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[Presentation] The 5'-untranslated region regulates the stability of ATF5mRNA by nonsense-mediated mRNA decay2011
Author(s)
Umemura, M., Hatano, M., Kimura, N., Yamazaki, T., Takeda, H., Nakano, H., Takahashi, S., Takahashi, Y.
Organizer
Cold spring harbor laboratory the 2011 meeting on eukaryotic mRNA processing
Place of Presentation
New York, USA
Year and Date
20110800
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[Presentation] Regulation of C/EBPγmRNA stability by environmental stresses2011
Author(s)
Yamazaki, T., Okawa, Y.,Watanabe, R., Murakoso, S., Nakano, H., Takahashi, S., Takahashi, Y.
Organizer
Cold spring harbor laboratory the 2011 meeting on eukaryotic mRNA processing
Place of Presentation
New York, USA
Year and Date
20110800
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