2013 Fiscal Year Final Research Report
Continuous luminescence of photoprotein with substrate analog
| Project/Area Number |
23580147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
KUSE MASAKI 神戸大学, (連合)農学研究科(研究院), 准教授 (40335013)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 生体分子 / 生理活性 / 蛋白質 / 有機化学 |
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| Research Abstract |
Attempts have been made to find the condition which enables photoprotein to emit light continuously. A suitable condition for re-generation of photoprotein was obtained by using chemically synthesized oxy-chromophore analog. A florescent substance of photoprotein was also synthesized. A substance analog, in which sulfur and fluorine atoms were incorporated, was finally synthesized. The analog showed high bioluminescent activity as natural substance. From these results, fundamental knowledge was accumulated to obtain continuous luminescence of photoprotein.
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[Journal Article] First synthesis of decaturin C, an antiinsectant diterpenoid iolatd from Penicillium thiersii2012
Author(s)
Nakazaki, K., Hayashi, K., Hosoe, S., Tashiro, T., Kuse, M., Takikawa, H.
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Journal Title
Tetrahedron
Volume: 68
Pages: 9029-9034
Peer Reviewed
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[Journal Article] Dynamic Chirality determines Critical Roles for Bioluminescence in Symplectin- Dehydrocoelenterazine System2011
Author(s)
Kongjinda, V., Nakashima, Y., Tani, N., Kuse, M., Nishikawa, T., Yu, CY. Harada, N., Isobe, M.
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Journal Title
Chem. Asian J
Volume: 6
Pages: 2080-2091
Peer Reviewed
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