2013 Fiscal Year Final Research Report
Integrated functionnal analyes of insulin-like peptides which regutate diapause and lifespan in Caenor habditis elegans
| Project/Area Number |
23580150
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IWASAKI Takashi 鳥取大学, 農学部, 助教 (30585584)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIGURO Masaji 新潟薬科大学, 応用生命化学部, 教授 (10280687)
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| Project Period (FY) |
2011 – 2013
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| Keywords | インスリン / 寿命 / 休眠 / 線虫 |
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| Research Abstract |
Insulin/IGF-1 signaling is known to regulate larval diapause and lifespan of the nematode Caenorhabditis elegans. So far, 40 of insulin-like genes have been identified in C. elegans. So far, 40 of insulin-like genes have been identified in C. elegans. In order to identify an insulin-like molecule which physiological function is unknown as well as to elucidate how insulin-like molecules co-operatively regulate diapause and lifespan, we performed three experiments as follows. 1, a functional analysis in "molecular level" using molecular modeling; 2, a functional analysis in "cellular level" using a primary culture; 3, a functional analysis in "organism level" using molecular biological technics. Moreover, we proposed a model for regulatory mechanism of expression of an insulin-like gene.
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[Journal Article] Vitamin B12 deficiency in Caenorhabditis elegans results in loss of fertility, extended life cycle, and reduced lifespan2013
Author(s)
Bito, T., Matsunaga, Y., Yabuta, Y., Kawano, T., Watanabe, F.
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Journal Title
FEBS OpenBio
Volume: 3
Pages: 112-117
Peer Reviewed
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[Journal Article] Physiological function, expression pattern, and transcriptional regulation of a Caenorhabditis elegans insulin-like peptide2012
Author(s)
Matsunaga, Y., Gengyo-Ando, K.,,Mitani, S., Iwasaki, T., and Kawano T.
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Journal Title
INS-18Biochem. Biophys. Res. Commun
Volume: 423
Pages: 478-483
Peer Reviewed
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[Journal Article] Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans2012
Author(s)
Honda, Y., Higashibara, A., Matsunaga, Y., Yonezawa, Y., Kawano, T., Higashitani, A.,Kuriyama, K., Shimazu, T., Fukui, K., Tanaka, M., Szewczyk, J N., Ishioka, N., and Honda, S.
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Journal Title
Scientific Reports
Volume: 2
Pages: 487-497
Peer Reviewed
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