2013 Fiscal Year Final Research Report
Functional analysis of novel terpene cyclases that resemble transporter
| Project/Area Number |
23580153
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Meiji University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | メロテルペノイド / 糸状菌 / テルペン環化酵素 / ポリケタイド / 生合成 |
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| Research Abstract |
Pyripyropene, produced by a fungus Aspergillus fumigatus, is a meroterpenoid that is expected to be developed as a cholesterol lowering drug. Among the pyripyropene biosynthetic gene cluster, a novel terpene cyclase was identified that resembled more like a transporter. In this study, detailed analysis of its active site residue was carried out. Besides, a second meroterpenoid biosynthetic gene cluster was identified from A. fumigatus as well as from a fungus Fusarium graminearum, which causes Fusarium head blight. The PKS among the second gene cluster in A. fumigatus was shown to produce TAL.
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Research Products
(1 results)
