2014 Fiscal Year Final Research Report
Low-carbon Green Synthesis of Bioactive Peptides Based on Fluoromics
| Project/Area Number |
23580154
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Meijo University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2014
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| Keywords | フルオロミクス / フルオラスタグ / 疎水性 / 触媒 / 全合成 / ペプチド / コンビナトリアル合成 |
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| Outline of Final Research Achievements |
A research that controls the molecular properties by the fluorous content in the molecule (fluoromix concept) was performed to achieve the energy-saving molecular synthesis. As a result, we got the following results.
1) Fluorous Mukaiyama reagent, which can achieve an easy condensation system, was developed. In this condensation reaction, the product can be isolated effectively from by-products after the reaction. 2) We found a divergent synthesis method of Fmoc reagents, which have different fluorous tags. 3) A concise liquid-phase combinatorial synthesis of all stereoisomers of tenuecyclamide A was achieved using a mixture of D/L-alanine with each stereoisomer encoded by a different f-Fmoc tag.
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| Free Research Field |
有機合成化学
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