2013 Fiscal Year Final Research Report
Study on the regulatory mechanisms of neurodegenelation by tryptophan key enzymes
| Project/Area Number |
23580158
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | トリプトファン / ナイアシン / キノリン酸 / 神経毒 / ミクログリア / 脳 |
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| Research Abstract |
Quinolinic acid (QA), a tryptophan metabolite, was observed to increase in brains of patients with neurodegenerative diseases. Indoleamine 2,3-deoxygenase (IDO) and amino carboxymuconate semialdehyde decarboxylase (ACMSD) affect QA production. In this study, we investigated the effect of some food components on IDO or ACMSD expression in microglial cells or LPS treated mice involved in neurodegenerative disease pathogenesis. Polyphenols in cereals suppressed IDO expression in microglial cells and in brain of LPS treated mice. Our results suggest that inhibition of the NF-kB pathway may be partly involved in the regulatory mechanism of IDO expression by polyphenols in cereals. We also found that phytol decreased ACMSD activity, its protein and mRNA expression. It is possible that this mechanism resulted from the activation of PPAR alpha. Some food components may be considered helpful for avoiding central nervous system inflammation.
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