2013 Fiscal Year Final Research Report
Molecular modeling of anti-amyloidal catechol derivatives using amyloidogenic proteins
| Project/Area Number |
23580161
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | Shinshu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUJII Hiroshi 信州大学, 農学部, 教授 (90165340)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HIGUCHI Keiichi 信州大学, 医学系研究科, 教授 (20173156)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | アミロイド性蛋白質 / 抗アミロイド効果 / カテコール誘導体 / 分子モデリング / 抗アミロイドーシス食品素材 |
|---|
| Research Abstract |
Molecular modeling of anti-amyloidal catechol derivatives was performed using Amyloid-beta, ApoA-II, human cystatin C and stefin B as model proteins. We prepared enzymatic lipophilized/glycosylated phenolic compounds in addition to mono- and di-catecholates of sesamin, and used for anti-amyloidal experiments. As the result, we found that there was a strong relationship between amphiphilicity and anti-amyloidal activity of tested phenolic compounds. We also found that lipophilic chain length introduced was an important factor in the anti-amyloidal activity of novel catechol derivatives.
|
