2013 Fiscal Year Final Research Report
Regulation of physiological functions with food factors via molecular chaperones
| Project/Area Number |
23580164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyoto University |
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Principal Investigator |
MURAKAMI Akira 京都大学, (連合)農学研究科(研究院), 助教 (10271412)
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| Project Period (FY) |
2011 – 2013
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| Keywords | zerumbone / heat shock protein / proteasome / autophagy / hormesis / stress / target molecule / molecular chaperone |
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| Research Abstract |
Although phytochemicals have been reported to exhibit various physiological functions, their underlying mechanisms remain to be fully elucidated. We previously identified Keap1 as a target molecule of zerumbone, a major component of Zingiber zerumbet. Concomitantly, however, we also observed numerous binding proteins when cells were exposed to this phytochemical. Thus this study focused on the role(s) of non-specific protein binding in its bioactivities. Interestingly, zerumbone-induced proteo-stress up-regulated the expressions of molecular chaperones and increased autophagy for degradation of abnormal proteins. This is the first study that showed phytochemical-induced proteo-stress has significant and unique roles in their bioactivities.
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Research Products
(13 results)
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[Remarks] ①村上 明 、体に良い食べ物、悪い食べ物 を考える食品機能学、兵庫県立兵庫高校 にて授業(2013年12月20日、神戸)(アウトリーチ活動)
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[Remarks] ②村上 明 、食べ物の健康効果を考える食 品機能学、兵庫県立兵庫高校にて授業 (2012年12月20日、神戸)(アウトリーチ活動)
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[Remarks] ③村上 明 、第46回日本農芸化学会サイエ ンスカフェ、野菜の成分は敵か味方か? ～体に良い理由(わけ)を考えよう～ (2012年2月28日、京都)(アウトリーチ活動)
