2013 Fiscal Year Final Research Report
Study on cytoprotective effects of tocotorienol in a cellular Parkinson's disease model
| Project/Area Number |
23580168
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKASO Kazuhiro 鳥取大学, 医学部, 准教授 (30379648)
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| Project Period (FY) |
2011 – 2013
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| Keywords | トコトリエノール / パーキンソン病 / αシヌクレイン / 非抗酸化作用 / シグナル伝達 / カベオリン |
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| Research Abstract |
In the present study, we investigated the cytoprptective effects of tocotrienol (T3) in cellular and murine Parkinson's disease (PD) models. All T3 homologues exerted cytoprptective effects via activation of PI3K/Akt signaling pathway in a cellular PD model. We also identified estrogen receptor (ER) beta as an upstream mediator of PI3K/Akt signaling and demonstrated the direct binding of T3 to ER beta in vitro. Furthermore, we revealed that T3 treatment relieved PD-related symptoms in PD model mice.
Our data have demonstrated that T3 elicits the cytoprotective effects via ER beta/PI3K/Akt signaling pathway in cellular and murine PD models.
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