2013 Fiscal Year Final Research Report
Studies on functional foods for anti-metabolic syndrome based on enhancements of mitochondrial functions
| Project/Area Number |
23580172
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyushu University |
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Principal Investigator |
TERUYA Kiichiro 九州大学, (連合)農学研究科(研究院), 助教 (10273971)
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| Project Period (FY) |
2011 – 2013
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| Keywords | メタボリックシンドローム / 機能性食品 / 細胞・組織 / シグナル伝達 / 生理活性 / エネルギー代謝 |
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| Research Abstract |
In vitro evaluation systems for mitochondrial function of myotubes were developed, and enhancing effects of mitochondrial functions were evaluated. The effectiveness of fermented milk Kefir was revealed. (1) Enhancing effects of energy metabolism in myotubes via activations 5'-AMP-activated protein kinase and acetyl-CoA carboxylase. (2) Enhancing effects of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha expression, which is the key molecule related to mitochondrial biogenesis. (3) Enhancing effects of cellular respiratory activities.
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[Journal Article] A rapid screening and production method using a novel mammalian cell display to isolate human monoclonal antibodies2013
Author(s)
Tomimatsu, K., Matsumoto, S.-E., Tanaka, H., Yamashita, M., Nakanishi, H., Teruya, K., Kazuno, S., Kinjo, T., Hamasaki, T., Kusumoto, K.-I., Kabayama, S., Katakura, Y., Shirahata, S.
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 441(1)
Pages: 59-64
DOI
Peer Reviewed
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[Journal Article] Low concentration platinum nanoparticles effectively scavenge reactive oxygen species in rat skeletal L6 cells2013
Author(s)
Nakanishi, H., Hamasaki, T., Kinjo, T., Yan, H., Nakamichi, N., Kabayama, S., Teruya, K., Shirahata, S.
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Journal Title
Nano Biomed. Eng
Volume: 5(2)
Pages: 76-85
DOI
Peer Reviewed
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[Journal Article] Protective effects of the fermented milk Kefir on X-ray irradiation-induced intestinal damage in B6C3F1 mice2013
Author(s)
Teruya, K., Myojin-Maekawa, Y., Shimamoto, F., Watanabe, H., Nakamichi, N., Tokumaru, K., Tokumaru, S., Shirahata, S.
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Journal Title
Biol. Pharm. Bull
Volume: 36(3)
Pages: 352-359
DOI
Peer Reviewed
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[Journal Article] Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells2012
Author(s)
Kinjo, T., Ye, J., Yan, H., Hamasaki, T., Nakanishi, H., Toh, K., Nakamichi, N., Kabayama, S., Teruya, K., Shirahata, S.
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Journal Title
Cytotechnol
Volume: 64 (3)
Pages: 357-371
DOI
Peer Reviewed
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[Journal Article] Suppressive effects of natural reduced waters on alloxan-induced apoptosis and type 1 diabetes mellitus2012
Author(s)
Li, Y., Hamasaki, T., Teruya, K., Nakamichi, N., Gadek, Z., Kashiwagi, T., Yan, H., Kinjo, T., Komatsu, T., Ishii, Y., Shirahata, S.
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Journal Title
Cytotechnol
Volume: 64 (3)
Pages: 281-297
DOI
Peer Reviewed
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[Journal Article] Mechanism of the lifespan extension of Caenorhabditis elegans by electrolyzed reduced water-participation of Pt nanoparticles2011
Author(s)
Yan, H., Kinjo, T., Tian, H., Hamasaki, T., Teruya, K., Kabayama, S., Shirahata, S.
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Journal Title
Biosci. Biotech. Biochem
Volume: 75(7)
Pages: 1295-1299
DOI
Peer Reviewed
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