2013 Fiscal Year Final Research Report
Clarification of the molecular targets for bioactive anthocyanins: MAP kinase as direct targets
| Project/Area Number |
23580176
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kagoshima University |
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Principal Investigator |
HOU De-Xing 鹿児島大学, 農学部, 教授 (90305160)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Fumio 鹿児島大学, 農学部, 教授 (70244142)
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| Project Period (FY) |
2011 – 2013
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| Keywords | アントシアニン / 細胞標的分子 / MAPキナーゼ / 親和力 / 直接結合能 / 結合モデル構築 / 細胞癌化抑制能 / 炎症抑制能 |
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| Research Abstract |
Although anthocyanin glycosides are major forms distributed in many plant foods and promised as chemopreventive source, molecular mechanisms remain unclear. This study aims to identify the molecular targets of bioactive anthocyanins using chemical biology methodologies. The results showed that bioactive anthocyanins had defined potential of affinity and binding to MAP kinases in the order of MEK > ERK > B-Raf without ATP-competitive manner. Therefore, bioactive anthocyanins suppressed the activation of these MAP kinase to prevent cell transformation and inflammation in mouse paw edema induced by carcinogens. On the other hand, the specific and inhibitory effects were weaker than that by the specific inhibitors of MAP kinases. These findings provide the molecular evidence for understanding the chemopreventive effects of bioactive anthocyanins.
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[Journal Article] Jun dimerization protein 2 is a critical component ofthe Nrf2/MafK complex regulating the response to ROS homeostasis2013
Author(s)
Tanigawa S, Lee CH, Lin CS, Ku CC, Hasegawa H, Qin S, Kawahara A, Korenori Y, Miyamori K, Noguchi M, Lee LH, Lin YC, Steve Lin CL, Nakamura Y, Jin C, Yamaguchi N, Eckner R, Hou DX, Yokoyama KK.
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Journal Title
Cell Death Dis
Volume: 4
Pages: e921
Peer Reviewed
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