2013 Fiscal Year Final Research Report
Novel anti-infection Drug-delivery strategy by using ovotransferrin and its domains
| Project/Area Number |
23580177
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 食品生化学 / Drug-delivery / Anti-infection / Transferrin receptor / Ovotransferrin / Antimicrobial |
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| Research Abstract |
The results demonstrate that ovotransferrin (OTf) binds different insoluble sulfa antibiotics and for complex in which these hydrophobic antibiotics become totally water soluble. The antibiotics-off complexes showed potent antimicrobial activity against several pathogens or either Gram-positive or Gram-negative strains. Strikingly, the complexes were able to reach and kill pathogens intracellularly infecting human colon cells (HCT-116), and the mechanism was found to be mediated through endocytosis via transferring receptor found at the surface of human cells. The finding herald a fascinating opportunity with potential application of OTf as drug carrier for the treatment of infectious diseases.
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[Journal Article] Effect of polymorphism in egg white lysozyme on muramidase and antibacterial activities as well as hatchability in the Japanese quail (Coturnix japonica)2012
Author(s)
Myint, S.L., Kinoshita, K., Shimogiri, T., Ibrahim, H.R., Tsusaki, T., Tanoue, T., Kawabe, K., Maeda, Y. and Okamoto, S.
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Journal Title
J. Anim. Sci. (JAS)
Volume: 90 (6)
Pages: 1747-1755
Peer Reviewed
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