2013 Fiscal Year Final Research Report
Chemical and biological studies on the functions of propolis
| Project/Area Number |
23580180
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUGIYAMA Yasumasa 鹿児島大学, 水産学部, 准教授 (90347386)
OHTA Toshiro 静岡県立大学, 大学院食品栄養環境科学研 究院, 助教 (40285193)
NAKAMURA Jun 玉川大学, ミツバチ科学研究センター, 教 授 (30256002)
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| Project Period (FY) |
2011 – 2013
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| Keywords | プロポリス / 起源植物 / ミツバチ / ソロモン諸島 / プレニルフラボノイド / 血管新生 |
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| Research Abstract |
Propolis is a natural resinous substance collected by honeybees from buds and exudates of certain trees and plants to protect their beehive from enemies. It is used as folk medicine in many regions of the world. In this study, chemical and biological methods were applied to evaluate the functions of propolis. In particular, chemical analyses of the propolis from Jeju (Korea) and the Solomon Islands were carried out, and we determined several new compounds from them. In addition, we searched for antiangiogenic compounds from propolis, the ethanol extracts of Okinawan propolis showed significant antiangiogenic activities in vitro and in vivo assay systems, and we evaluated the modes of action of antiangiogenic effects of the major component of Okinawan propolis, nymphaeol-A by investigating the inhibition of tube formation, as well as changes in survival signals and apoptotic pathways using human umbilical vein endothelial cells.
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[Journal Article] Solophenols B-D and solomonin : new prenylated polyphenols isolated from propolis collected from the Solomon Islands and their antibacterial activity2012
Author(s)
Saori Inui, Takahiro Hosoya, Yuko Shimamura, Shuichi Masuda, Takeshi Ogawa, Hirokazu Kobayashi, Kenichi Shirafuji, Reuben Toli Moli, Ikue Kozone, Kazuo Shin-ya, Shigenori Kumazawa
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Journal Title
Journal of Agricultural and Food Chemistry
Volume: 60
Pages: 11765-11770
DOI
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[Journal Article] Identification of the plant origin of propolis from Jeju Island, Korea, by the observatioh of honeybee behavior and phytochemical analysis.2012
Author(s)
Kohsuke Shimomura, Saori Inui, Yasumasa Sugiyama, Miho Kurosawa, Jun Nakamura, Su-Jin Choi, Mok-Ryeon Ahn, Shigenori Kumazawa
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Journal Title
Bioscience Biotechnology, and Biochemistry
Volume: 76
Pages: 2135-2138
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