2013 Fiscal Year Final Research Report
Anti-diabetes and its mechanism using food factors via incretin action.
| Project/Area Number |
23580187
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Chubu University |
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Principal Investigator |
TSUDA Takanori 中部大学, 応用生物学部, 准教授 (90281568)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 食品成分 / 糖尿病 |
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| Research Abstract |
Increase endogenous GLP-1 secretion from intestinal L cells by food factors is one of the crucial targets for prevention and treatment of diabetes. In the present study, we demonstrate that curcumin, a yellow pigment, significantly increases GLP-1 secretion in L cells model, and we clarified the structure activity relationship using curcumin derivatives. Also, concerning the secretory mechanism, the significant increase in GLP-1 secretion by curcumin involved the CaMKII pathway, and was independent of extracellular signal-regulated kinase, PKC, and the cAMP/PKA-related pathway.
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Research Products
(30 results)
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[Journal Article] Stimulation of glucose uptake by theasinensins through the AMP-activated protein kinase pathway in rat skeletal muscle cells2014
Author(s)
Ju Qiu, J., Maekawa, K., Kitamura, Y., Miyata, Y., Tanaka, T., Tanaka , T., Soga, M., Tsuda, T., Matsui, T.
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Journal Title
Biochem. Pharmacol
Volume: 87
Pages: 344-351
Peer Reviewed
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[Journal Article] Black soybean seed coat extract ameliorates hyperglycemia and insulin sensitivity via the activation of AMP-activated protein kinase in diabetic mice2013
Author(s)
Kurimoto, Y., Shibayama, Y., Inoue, S., Soga, M., Takikawa, M., Ito, C., Nanba, F., Yoshida, T., Yamashita, Y., Ashida, H., Tsuda, T.
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Journal Title
J. Agric. Food Chem
Volume: 61
Pages: 5558-64
Peer Reviewed
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[Journal Article] 10-hydroxy-2-decenoic acid, a unique medium-chain fatty acid, activates AMP-activated protein kinase in L6 myotubes and mice2013
Author(s)
Takikawa, M., Kumagai, A., Hirata, H., Soga, M., Yamashita, Y., Ueda, M., Ashida, H., Tsuda, T.
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Journal Title
Mol. Nutr. Food. Res
Volume: 57
Pages: 1794-802
Peer Reviewed
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[Journal Article] Genistein and daidzein, typical soy isoflavones, inhibit TNF-α-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes2012
Author(s)
Yanagisawa, M., Sugiya, M., Iijima, H., Nakagome, I., Hirono, S., Tsuda, T.
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Journal Title
Mol. Nutr. Food Res
Volume: 56
Pages: 1783-93
Peer Reviewed
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[Journal Article] Brazilian propolis-derived components inhibit TNF-α-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes2011
Author(s)
Ikeda, R, Yanagisawa, M., Takahashi, N., Kawada, T., Kumazawa, S., Yamaotsu, N., Nakagome, I., Shuichi Hirono, S., Tsuda, T.
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Journal Title
Biochim. Biophys. Acta
Volume: 1810
Pages: 695-703
Peer Reviewed
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[Journal Article] A black soybean seed coat extract prevents obesity and glucose intolerance by up-regulating uncoupling proteins and down-regulating inflammatory cytokines in high-fat diet-fed mice2011
Author(s)
Kanamoto, Y., Yamashita, Y., Namba, F., Yoshida, T., Tsuda, T., Fukuda, I., Nakamura-Tsuruta, S., and Ashida, H.
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Journal Title
J. Agric. Food Chem
Volume: 59
Pages: 8985-93
Peer Reviewed
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[Journal Article] Oral toxicological studies of black soybean (Glycine max) hull extract:Acute studies in rats and mice, and chronic studies in mice. 2011.112011
Author(s)
Fukuda, I., Tsutsui, M., Yoshida, T., Toda, T., Tsuda, T., Ashida, H.
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Journal Title
Food Chem. Toxicol
Volume: 49
Pages: 3272-78
Peer Reviewed
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