2013 Fiscal Year Final Research Report
Metabolic conversion of dietary xanthophylls and their actions on oxidative stress induced by light irradiation
| Project/Area Number |
23580189
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | National Agriculture and Food Research Organization |
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Principal Investigator |
NAGAO Akihiko 独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所・食品素材科学研究領域, 上席研究員 (40353958)
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| Co-Investigator(Kenkyū-buntansha) |
KOTAKE Eiichi 独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所・食品素材科学研究領域, 主任研究員 (20547236)
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| Project Period (FY) |
2011 – 2013
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| Keywords | キサントフィル / ルテイン / ゼアキサンチン / β－クリプトキサンチン / 酸化的代謝 / NO産生 / 光酸化安定性 / 抗炎症 |
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| Research Abstract |
Oxidative metabolism of dietary xanthophylls was elucidated by analyzing the metabolic activity of mouse liver. The 3-hydroxy beta-end group of xanthophylls was converted to 3-oxo epsilon-end group, via an intermediate having 3-oxo beta-end group, which was produced by dehydrogenation dependent on a coenzyme NAD. This metabolic reaction might be involved in eliminating xanthophylls from the tissues, because of the intermediate was extremely unstable. Stability of carotenoids accumulated in cultured cells exposed to blue-light irradiation was found to be quite different among carotenoids with diverse structures.
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