2013 Fiscal Year Final Research Report
Mechanism of degradation of paralytic shellfish toxin by polyphenols
| Project/Area Number |
23580284
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | Kitasato University |
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Principal Investigator |
SATO Shigeru 北里大学, 海洋生命科学部, 准教授 (20170748)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 麻痺性貝毒 / ポリフェノール / 酸化還元電位 / 酸化分解 / 没食子酸 |
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| Research Abstract |
Polyphenols (PPs) such as gallic acid and its derivatives in wine and tea were revealed to decompose 11-reduced paralytic shellfish toxins (PST). It was reported that incubation of PST with strong oxidants in such as hydro peroxide in basic solution gives fluorescent purines. A same purine derivative was found in the reaction mixture of PPs and PST after mild incubation in neutral aquatic solution. Addition of PPs to neutral phosphate buffer reduced oxidation-reduction potential of the solution, and enhanced the oxidation-degradation of PST. These findings indicate that oxidized PPs react with PST, or PPs act as effective catalysts to oxidize PST by dissolved oxygen.
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