2013 Fiscal Year Final Research Report
Studies on the development of feedback mechanisms of the pituitary-thyroid axis of the chick embryo
| Project/Area Number |
23580387
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied animal science
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| Research Institution | Gifu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 代謝・内分泌制御 / ニワトリ / 甲状腺刺激ホルモン / 甲状腺ホルモン |
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| Research Abstract |
The hypothalamus-pituitary-thyroid axis is one of the important homeostatic regulatory systems of higher vertebrates. This research was undertaken using chick embryos for the purpose of clarifying at what stages of their development the components of this axis emerge and start functioning. The results obtained suggested that in the peripheral organs from before day 12 of incubation regulation by small amounts of circulating thyroid hormones and peripheral deiodinases were functioning according to the demand of each developing organ, and that top-down regulation by thyrotropin released from the pituitary played an important role around hatching when large amounts of circulating thyroid hormones were necessary.
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