2013 Fiscal Year Final Research Report
Sexual maturation in Growth hormone receptor deficiency chicken.
| Project/Area Number |
23580389
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied animal science
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| Research Institution | Nagoya University |
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Principal Investigator |
TSUKADA Akira 名古屋大学, 生命農学研究科, 助教 (20343212)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 成長ホルモン / 成長ホルモン受容体 / 成長ホルモン作用 / 精巣 / セルトリ細胞 / ライディッヒ細胞 / 精原細胞 |
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| Research Abstract |
Growth hormone (GH) plays a various role in controlling cell proliferation and development, nutrient metabolism, protein synthesis and reproduction as well as normal growth. GH actions are exerted after binding to GH receptor (GHR) localized in target tissues. Sex-linked dwarf (SLD) chicken lacking functional GHR is good experimental model for study of GH actions. We investigated effect of GHR deficiency on sexual maturation in chicken. Testicular GHR mRNA was expressed at 5-12 weeks old in male. Testicular GHR mRNA expression was high until 12 weeks old, but which was not detected in 16-weeks old and matured males. Maturation of seminiferous tubule in male was delayed in SLD chicken. Present results suggested that GH was directly or indirectly affected to sexual maturation. Especially, negative correlation with GHR mRNA expression and area of testicular tuble was suggested that GH strongly effect on testicular development, before spermatogenesis.
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