2013 Fiscal Year Final Research Report
In vitro growth of porcine growing oocytes
| Project/Area Number |
23580397
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied animal science
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| Research Institution | Kinki University |
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Principal Investigator |
HASHIMOTO Shu 近畿大学, 生物理工学部, 研究員 (30570949)
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| Co-Investigator(Kenkyū-buntansha) |
HOSOI Yoshihiko 近畿大学, 生物理工学部, 教授 (70192739)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 発生工学 / 生殖工学 / 生殖医療 / 卵母細胞 |
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| Research Abstract |
We have focused attention on the mitochondrial activity of in vitro grown (IVG) oocytes and shown that L-Carnitine, which acts as a carrier of fatty acids across the inner mitochondrial membrane for subsequent beta-oxidation, supported the viability of growing oocytes. Moreover, we have successfully obtained fertilized ova by ICSI which developed from growing oocytes in vitro.
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[Journal Article] Hippo Signaling Disruption and Akt Stimulation of Ovarian Follicles for Infertility2013
Author(s)
Kawamura K, Cheng Y, Suzuki N, Deguchi M, Sato Y, TakaeS, Ho CH, Kawamura N, Tamura M, Hashimoto S, Sugishita Y, Morimoto Y, Hosoi Y, Yoshioka N, Ishizuka B, Hsueh AJ.
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Journal Title
Proc Nat Acad Sci USA
Volume: 110
Pages: 17474-17479
DOI
Peer Reviewed
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