2013 Fiscal Year Final Research Report
Expression profiles of G-protein coupled receptors in gonadotropin-releasing hormone neurons
| Project/Area Number |
23580402
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OISHI Shinya 京都大学, 大学院薬学研究科, 講師 (80381739)
ISHII Hirotaka 日本医科大学, 医学部, 講師 (20445810)
SUWA Makiko 独立行政法人産業技術総合研究所, 生命情報 工学研究センター, 主幹研究員 (30242241)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 神経ペプチド / GnRH / GPCR / LH / ラット |
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| Research Abstract |
Transcriptome analysis with Sevens, a database of G-protein coupled receptors (GPCR), showed the expression profiles of GPCR in gonadotropin-releasing hormone (GnRH) neurons obtained from GnRH-green fluorescent protein transgenic mice. Among those GPCR, kisspeptin receptor GPR54 is considered as a key molecule controlling GnRH secretion. This study also showed brain region specific enhancer of Kiss1 gene and histone acetylation and chromatin loop formation are responsible for Kiss1 gene up-regulation.
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Research Products
(53 results)
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[Journal Article] Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats2013
Author(s)
Nakahara T, Uenoyama Y, Iwase A, Oishi S, Nakamura S, Minabe S, Watanabe Y, Deura C, Noguchi T, Fujii N, Kikkawa F, Maeda K-I, Tsukamura H.
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Journal Title
J Reprod Dev
Volume: 59
Pages: 479-484
Peer Reviewed
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[Journal Article] Epigenetic regulation of Kiss1 gene expression mediating estrogen-positive feedback action in the mouse brain2012
Author(s)
Tomikawa J, Uenoyama Y, Ozawa M, Fukanuma T, Takase K, Goto T, Abe H, Ieda N, Minabe S, Deura C, Inoue N, Sanbo M, Tomita K, Hirabayashi M, Tanaka S, Imamura T, Okamura H, Maeda K-I, Tsukamura H.
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Journal Title
Proc Natl Acad Sci U S A
Volume: 109
Pages: E1294-1301
Peer Reviewed
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[Journal Article] Ultrastructural evidence of kisspeptin-gonadotrophin-releasing hormone interaction in the median eminence of female rats : Implication of axo-axonal regulation of GnRH release2011
Author(s)
Uenoyama Y, Inoue N, Pheng V, Homma T, Takase K, Yamada S, Ajiki K, Ichikawa M, Okamura H, Maeda K-I, Tsukamura H.
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Journal Title
J Neuroendocrinol
Volume: 23
Pages: 863-870
Peer Reviewed
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[Journal Article] Kisspeptin neurons mediate reflex ovulation in the musk shrew (Suncus murinus)2011
Author(s)
Inoue N, Sasagawa K, Ikai K, Sasaki Y, Tomikawa J, Oishi S, Fujii N, Uenoyama Y, Ohmori Y, Yamamoto N, Hondo E, Maeda K, Tsukamura H.
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Journal Title
Proc Natl Acad Sci U S A
Volume: 108
Pages: 17527-17532
Peer Reviewed
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[Presentation] Synchronized intracellular Ca^<2+> oscillations in cultured kisspeptin/neurokinin B/dynorphin-GFP neurons obtained from the hypothalamic arcuate nucleus of transgenic mice2013
Author(s)
Ikegami K, Abe H, Haruta T, Minabe S, Goto T, Sanbo M, Tamura C, Hirabayashi M, Uenoyama Y, Maeda K-I, Tsukamura H.
Organizer
Neuroscience 2013
Place of Presentation
San Diego, California
Year and Date
20131109-13
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[Presentation] Region-specific enhancer for Kiss1 expression in the Hypothalamic arcuate nucleus of female mice2013
Author(s)
Goto T, Tomikawa J, Abe H, Fukanuma T, Imamura T, Takase K, Sanbo M, Tomita K, Hirabayashi M, Tsukamura H, Maeda K-I, Uenoyama Y.
Organizer
Neuroscience 2013
Place of Presentation
San Diego, California
Year and Date
20131109-13
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[Presentation] Kisspeptin neurons mediate excitatory amino acid-induced luteinizing horomone secretion in rats2012
Author(s)
Ikegami K, Uenoyama Y, Nakamura S, Tomikawa J, Goto T, Sanbo M, Tamura C, Hirabayashi M, Maeda K-I, Tsukamura H.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Year and Date
20121106-09
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[Presentation] Establishment of primary kiss1 neuron culture for the analysis of gonadotropin-releasing hormone pulse generating system using kiss1-GFP transgenic mouse2012
Author(s)
Abe H, Haruta T, Goto T, Fukanuma T, Takase K, Sanbo M, Tomita K, Hirabayashi M, Imamura, T, Tomikawa J, Uenoyama Y, Maeda K-I, Tsukamura H.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Year and Date
20121106-09
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[Presentation] Kiss1 knockout rats to define role of kisspeptin in regulating luteinizing hormone secretion2012
Author(s)
Uenoyama Y, Nakamura S, Hayakawa, Y, Minabe S, Tomikawa J, Goto T, Ieda N, Sanbo M, Tamura C, Hirabayashi M, Maeda K-I, Tsukamura H.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Year and Date
20121106-09
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[Presentation] Kiss1 gene is required for defeminization of the brain controlling sexual behaviors in rats2012
Author(s)
Nakamura S, Uenoyama Y, Ikegami K, Tomikawa J, Goto T, Sanbo M, Tamura C, Hirabayashi M, Maeda K-I, Tsukamura H.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Year and Date
20121106-09
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[Presentation] Kiss1 upstream region regultes hypothalamic arcuate nucleus-specific kisspeptin expression2012
Author(s)
Goto T, Tomikawa J, Abe H, Fukanuma T, Imamura, T, Takase K, Sanbo M, Tomita K, Hirabayashi M, Tsukamura H, Maeda K-I, Uenoyama Y.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Year and Date
20121106-09
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