2013 Fiscal Year Final Research Report
Exploring a novel therapeutic agent for the treatment of brain edema based on the function of astrocytes
| Project/Area Number |
23580408
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
MORIYAMA Mitsuaki 大阪府立大学, 生命環境科学研究科(系), 准教授 (20275283)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Yoichi 大阪府立大学, 生命環境科学研究科, 教授 (90180413)
TAKANO Katsura 大阪府立大学, 生命環境科学研究科, 助教 (50453139)
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| Project Period (FY) |
2011 – 2013
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| Keywords | アンモニア / 浮腫 / 肝性脳症 / アストロサイト / 生理学 / 神経化学 |
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| Research Abstract |
Cerebral edema is an important complication of hepatic encephalopathy and traumatic brain injury and astrocyte swelling appears to be primarily responsible for the edema. We investigated the effects of inhibitors of Na+-K+-2Cl- cotransporter 1 (NKCC1), an ion transporter responsible for cell volume regulation, on astrocyte swelling. Ammonia induced MAP kinase activation and increased NKCC1 activity, which resulted in astrocyte swelling. Inhibition of this activity by MAP kinase inhibitors or anti-oxidant diminished ammonia-induced astrocyte swelling. Our results in the present study suggest that MAP kinase inhibitor and anti-oxidant may be effective therapeutic agents for brain edema.
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[Journal Article] A dibenzoylmethane derivative protects against hydrogen peroxide-induced cell death and inhibits lipopolysaccharide- induced nitric oxide production in cultured rat astrocytes2011
Author(s)
Takano K, Sugita K, Moriyama M, Hashida K, Hibino S, Choshi T, Murakami R, Yamada M, Suzuki H, Hori O, Nakamura Y.
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Journal Title
Journal of Neuroscience Research
Volume: 89
Pages: 955-965
DOI
Peer Reviewed
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