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2013 Fiscal Year Final Research Report

Identification of lesions responsible for fatal outcome in rats infected with Borna disease virus

Research Project

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Project/Area Number 23580414
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionAzabu University

Principal Investigator

HIROO MADARAME  麻布大学, 大学病院, 教授 (20173768)

Co-Investigator(Renkei-kenkyūsha) NISHINO Yoshii  京都産業大学, 総合生物科学部, 准教授 (00271544)
Project Period (FY) 2011 – 2013
Keywordsボルナ病 / ボルナウイルス / 中枢神経系
Research Abstract

Newborn rats were inoculated intracranially with CRNP5 variant of Borna disease virus (BDV) with severe pathogenesis, CRP3 BDV variant with mild pathogenesis, and nine recombinant BDV (rBDV) variants and examined for 8 weeks. 1. The CRNP5 had the highest score for incidence and severity of Borna disease (BD). Four groups of rBDV variants had a higher score than CRP3. 2. The body weight increase of four rBDV variants was lower than that of other rBDV variants and CRP3 from day 20 after inoculation. 3. All BDV inoculated brains were positive for anti BDV antibodies immunohistochemically. The virus titer for pup fatalities was significantly higher than that of pups on termination. 4. Four rBDV variants including L1(L1417R) mutation had higher scores for the severity of perivascular cuffing of mononuclear cells and L1(L1417R) may play an important role for the pathogenicity of BD. 5. Menigoencephalitis was observed only in rBDV variants. The pup fatalities had higher scores.

  • Research Products

    (3 results)

All 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Cutaneous Squamous Cell Carcinoma presenting as a Wound with Discharging

    • Author(s)
      M. Mwase, C. Mumba, D. Square, S. Kawarai and H. Madarame
    • Journal Title

      Sinus Tracts in a Wild African Lion(Panthera leo)

      Volume: 149 Pages: 520-523

    • Peer Reviewed
  • [Presentation] 不活性型Smad3発現マウスにおけるボルナ病ウイルス感染病態の解析2011

    • Author(s)
      内田裕子, 他
    • Organizer
      第152回日本獣医学会
    • Place of Presentation
      大阪府立大学
    • Year and Date
      2011-09-20
  • [Presentation] Neurovirulence of Borna disease virus in infected nude rats2011

    • Author(s)
      Y. Nishino, 他
    • Organizer
      International Union of Microbiological Societies Congress (IUMS) 2011
    • Place of Presentation
      Sapporo
    • Year and Date
      2011-09-13

URL: 

Published: 2015-07-16  

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