2013 Fiscal Year Final Research Report
Clinical application of autophagy-inducing factors from food supplements
| Project/Area Number |
23580417
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Shiga University of Medical Science (2012-2013)
National Center of Neurology and Psychiatry (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Ken 独立行政法人 国立精神・神経医療研究センター, 疾病研究第二部, 室長 (30392418)
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| Project Period (FY) |
2011 – 2013
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| Keywords | オートファジー / 小胞体ストレス / ミスフォールド蛋白質 / 食品成分 |
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| Research Abstract |
Accumulation of misfolded protein is a common pathological feature of many neurodegenerative disorders. Activation of autophagy is focused on an effective therapy against these diseases. Based on safety, I tried to perform clinical application of autophagy-inducing factors derived from food supplements. I first screened autophagy-inducing supplements from a food library using green fluorescence protein fused with microtuble associated protein 1 light chain 3, and identified three novel autophagy-induceing factors.
I also contributed to clarify protective effects of curcumin, an effective component of the curry spice tumeric, and known as an autophagy-inducing food supplement, against Pelizaeus-Merzbacher disease caused by endoplasmic reticulum stress. Furthermore, I demonstrated that chloroquine, which is used as an anti-maralia drug and well-known as an anti-autophagy compound, attenuates endoplasmic reticulum stress of the same disease by blocking protein translation.
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[Journal Article] Aberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43)2013
Author(s)
Shodai A, Morimura T, Ido A, Uchida T, Ayaki T, Takahashi R, Kitazawa S, Suzuki S, Shirouzu M, Kigawa T, Muto Y, Yokoyama S, Takahashi R, Kitahara R, Ito H, Fujiwara N, Urushitani M.
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Journal Title
J. Biol. Chem
Volume: 288
Pages: 14886-14905
Peer Reviewed
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[Presentation] Preclinical studies for the treatment of Pelizaeus-Merzbacher disease with clinically applicable compounds, curumin and chloroquine2013
Author(s)
Inoue K, Morimura T,Numata Y,Yu L-H, Gotoh L, Yamamoto R, Inoue N, Antalfy B, Deguchi K, Osaka H, Goto Y.
Organizer
23rd Meeting of the European Neurological Society
Place of Presentation
Barcelona, Spain (一般)
Year and Date
20130608-11
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[Presentation] Treating Pelizaeus-Merzbacher disease with clinically applicable compounds, curumin and chloroquine : preclinical studies2012
Author(s)
Inoue K, Morimura T, Numata Y, Yu, H, Gotoh L, Yamamoto R, Inoue N, Antalfy B, Deguchi K, Osaka H, Goto Y.
Organizer
62nd Annual meeting of the American Society of Human Genetics
Place of Presentation
San Francisco, USA(一般)
Year and Date
2012-11-08
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