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2013 Fiscal Year Final Research Report

Analysis of mechanism for the acquisition of infectivity by avian influenza virus in chickens

Research Project

  • PDF
Project/Area Number 23580432
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied veterinary science
Research InstitutionKyoto Sangyo University

Principal Investigator

TAKAKUWA Hiroki  京都産業大学, 総合生命科学部, 准教授 (20449507)

Project Period (FY) 2011 – 2013
Keywords鳥インフルエンザウイルス / 宿主域 / 感受性
Research Abstract

To provide information on the mechanism of acquisition of infectivity by avian influenza virus in chickens, we compared the complete sequences of H3N8 virus isolated from chickens and ducks. Seven amino acid substitutions were detected in the hemagglutinin (HA), matrix 2 (M2), and nonstructural 2 (NS2) proteins. Especially, three substitutions were detected at the position of 128, 137, and 145 on the globular head in the HA protein. These results suggest that these three amino acids in HA protein are related to the infectivity of avian influenza virus in chickens. Further studies using reverse genetics procedures, the HA genes of chicken and duck recombinant avian influenza virus strains were exchanged, are therefore necessary to clarify this issue.

  • Research Products

    (4 results)

All 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Molecular epidemiology of avian influenza viruses circulating among healthy poultry flocks in farms in northern Vietnam2012

    • Author(s)
      H. Takakuwa, T. Yamashiro, M. Q. Le, L. S. Phuong, H. Ozaki, R. Tsunekuni, T. Usui, H. Ito, M. Morimatsu, Y. Tomioka, T. Yamaguchi, T. Ito, T. Murase, E. Ono, K. Otsuki
    • Journal Title

      Preventive Veterinary Medicine

      Volume: Vol.103 Pages: 192-200

    • Peer Reviewed
  • [Journal Article] Isolation and characterization of H6N1 and H9N2 avian influenza viruses from ducks in hanoi2012

    • Author(s)
      K. Hotta, H. Takakuwa, Q. M. T. Le, S. L. Phuong, T. Murase, E. Ono, T. Ito, K. Otsuki, and T. Yamashiro
    • Journal Title

      Vietnam., Virus Research

      Volume: Vol.163 Pages: 448-453

    • Peer Reviewed
  • [Presentation] Molecular epidemiology of avian influenza viruses circulating among healthy duck flocks in farms in northern Vietnam during year 2006-20102012

    • Author(s)
      H. Takakuwa, T. Usui, K. Hotta, M. Q. Le, L. S. Phuong, R. Tsunekuni, H. Ozaki, H. Ito, M. Morimatsu, Y. Tomioka, T. Yamaguchi, T. Ito, T. Murase, E. Ono, T. Yamashiro, K. Otsuki
    • Organizer
      アジアリサーチフォーラム
    • Place of Presentation
      神戸
    • Year and Date
      20120111-12
  • [Remarks]

    • URL

      http://www.kyoto-su.ac.jp/graduate/g_eng/g_bio/kyoin/takakuwa.html

URL: 

Published: 2015-07-16  

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