2013 Fiscal Year Final Research Report
Novel long-lasting kisspeptin derivatives stimulate luteinizing hormone secretion in bovine
| Project/Area Number |
23580440
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIBATA Masahiro 独立行政法人農業・食品産業技術総合研究機構, 近畿中国四国農業研究センター, 主任研究員 (60370631)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 臨床繁殖 / 性腺刺激ホルモン |
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| Research Abstract |
Kisspeptin is a peptide hormone that acts as the principal positive regulator of the reproductive axis by stimulating luteinizing hormone (LH) from pituitary. In order to develop new medicine, this study investigated whether various modification of the C-terminal residue of bovine kisspeptin can potentiate the LH-stimulating ability, and have long-lasting pharmacological effects. Some of modification induced the secretion of LH from cultured bovine pituitary cells to a greater degree and longer-lasting than unmodified kisspeptin. In next, we tried to inject the best candidate of new drugs into heifers and postpartum dairy cows. The best candidate stimulated LH secretion in heifers, although it had no significant effect on LH secretion in postpartum dairy cows. Therefore, we developed novel long-lasting kisspeptin derivatives stimulate luteinizing hormone secretion in bovine.
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