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2013 Fiscal Year Final Research Report

Development of the new treatment, prophylaxis of the phylum Apicomplexa

Research Project

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Project/Area Number 23580445
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Clinical veterinary science
Research InstitutionOsaka Prefecture University

Principal Investigator

SASAI Kazumi  大阪府立大学, 生命環境科学研究科(系), 教授 (70211935)

Co-Investigator(Kenkyū-buntansha) TANI Hiroyuki  大阪府立大学, 生命環境科学研究科, 准教 授 (00305658)
FURUYA Masaru  大阪府立大学, 生命環境科学研究科, 助教 (30500706)
MATSUBAYASHI Makoto  独立行政法人 農業・食品産業総合研究機構, 動物衛生研究所, 主任研究員 (00321076)
Project Period (FY) 2011 – 2013
KeywordsApicomplexa / Apical complex / モノクローナル抗体 / 感染防御
Research Abstract

The antigens in apical complex of Cryptosppridium parvum and Plasmodium berghei recognized were analyzed by monoclonal antibody (mAB) .From these results, the possibility that EF-1a played the role that was important to the host cells invasion due to the parasitic worm was suggested.Thus, the possibility that the antigen which mAB recognized was the antigen which could become a vaccine candidate for the cryptosporidiosis and Malaria was suggested.

  • Research Products

    (2 results)

All 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Elongation Factor-1αis a Novel Protein Associated with Host Cell Invasion and a Potential Protective Antigen of Cryptosporidium parvum2013

    • Author(s)
      Matsubayashi M, Kimata I, Uni S, Lillehoj HS, Matsuda H, Furuya M, Tani H, and Sasai K.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 288(47) Pages: 34111-34120

    • DOI

      10.1074/jbc.M113.515544

    • Peer Reviewed
  • [Journal Article] Infectivity of Cryptosporidium andersoni Kawatabi type relative to the small number of oocysts in immunodeficient and immunocompetent neonatal and adult mice2013

    • Author(s)
      Koyashiki-Nagano S., Matsubayashi M., Kimata I., Furuya M., Tani H., Sasai K.
    • Journal Title

      Parasitol. Int

      Volume: 62(2) Pages: 109-111

    • DOI

      10.1016/j.parint.2012.11.001

    • Peer Reviewed

URL: 

Published: 2015-07-16  

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