2013 Fiscal Year Final Research Report
Effect of ketone body to peripheral gd T cell function in dairy cows during the breeding periods
| Project/Area Number |
23580448
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Clinical veterinary science
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OSAWA Takeshi 宮崎大学, 農学部, 教授 (90302059)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 乳牛 / ケトン体 / 繁殖適期 / T細胞 |
|---|
| Research Abstract |
Dairy cows are at an increased risk for disorders during early lactation. At this time, there is increasing milk production, but a lag in feed intake, and this condition results in the production of the ketone body in the cows with negative energy balance. Although hyperketonemia should be minimized to prevent undesirable effects on immune function and reproduction, effect of ketone body to T cell function was investigated in this study. Increased IL-17 as a family functions as a proinflammatory cytokine that responds to the invasion of the immune system and decreased IL-4 as an anti-inflammatory cytokine that responds to the gestation were observed in the cows with hyperketonemina. In the comparison of T cell, gd T cell express strongly IL-17 mRNA and CD4+ T cell express strongly IL-4 mRNA in cows, therefore it was possible that ketone bodies induce an inappropriate immune condition for conception by activative effect to gd T cells and suppressive effect to CD4+ T cells.
|
-
[Journal Article] Effect of oral supplementation of bamboo grass leaves extracts supplement on cellular immune function in dairy cows2014
Author(s)
Ohtsuka, H., Fujiwara, H., Nishio, A., Sakai, Y., Matsuda, K, Muramatsu, Y., Hara, H., Nakagawa-Yagi, Y., Hara, T.
-
Journal Title
Acta Veterinaria Brno
Volume: (in press)
-
[Journal Article] Effect of Escherichia coli and Staphylococcus aureus on the in vitro response of peripheral blood mononuclear cells isolated from Holstein dairy cows had ketosis or milk fever of field cases2014
Author(s)
Ohtsuka, H., Kanikawa, N., Kudo, K., Kyutoku, F., Kakinuma, S., Kohno, M., Maeda, Y. and Tanabe, T.
-
Journal Title
Int. J. Anim. Vet. Adv
Volume: (in press)
-
[Journal Article] Changes in Leukocyte Populations of the Cows with Milk Fever or Displaced Abomasum after Calving2013
Author(s)
Ohtsuka, H., Fukuda, S., Kudo, K., Tomioka, M., Koiwa, K. and Kimura, K.
-
Journal Title
Can. J. Vet. Res
Volume: 77
Pages: 226-230
-
[Journal Article] Gene expression in T lymphocytes of gravid cows during preimplantation2013
Author(s)
Maeda, M., Yamamoto, K., Ohtsuka, H., Ando, T., Tomioka, M., Oikawa, M.
-
Journal Title
Acta Veterinaria Brno
Volume: 82
Pages: 131-134
-
-
[Journal Article] Effect of Progesterone on the In Vitro Response of Peripheral Blood Mononuclear Cells Stimulated by Escherichia coli in Mares2012
Author(s)
Maeda, Y., Ohtsuka, H., Tomioka, M., Tanabe, T., Nanbo, Y., Uematsu, H. and Oikawa, M.
-
Journal Title
J. Vet. Med. Sci
Volume: 74
Pages: 629-632
-
-
-
-
-
-
-
-
-
