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2013 Fiscal Year Final Research Report

The effects of various heart failure medications on heart rate variability and renin-angiotensin aldosterone system in dogs with mitral regurgitation.

Research Project

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Project/Area Number 23580449
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Clinical veterinary science
Research InstitutionAzabu University

Principal Investigator

FUJII Yoko  麻布大学, 獣医学部, 教授 (10318884)

Project Period (FY) 2011 – 2013
Keywords心拍変動 / 慢性変性性房室弁疾患 / 内科治療 / 犬
Research Abstract

The purpose of this study was to evaluate the effects of various medication used for heart failure on autonomic tone and renin-angiotensin aldosterone system (RAAS) in dogs with chronic valvular heart disease. Five dogs with experimentally induced mitral regurgitation were used. Furosemide, furosemide and pimobendan, combination of furosemide, pimobendan and enaralril, azosemide and placebo were administered in the cross-over design. Variables of heart rate variability were not significantly different among groups. Urine aldosterone creatinine ratio was increased due to furosemide, however, concurrent administration of enalapril did not seem to suppress RAAS activation. Azosemide appeared minimally influence to RAAS.

  • Research Products

    (1 results)

All 2014

All Presentation (1 results)

  • [Presentation] 心機能と心外臓器の関わり2014

    • Author(s)
      藤井洋子
    • Organizer
      JCVIM(日本獣医内科学アカデミー)
    • Place of Presentation
      横浜
    • Year and Date
      20140200

URL: 

Published: 2015-07-16  

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