2013 Fiscal Year Final Research Report

The effects of various heart failure medications on heart rate variability and renin-angiotensin aldosterone system in dogs with mitral regurgitation.

Research Project

Project/Area Number	23580449
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Clinical veterinary science
Research Institution	Azabu University
Principal Investigator	FUJII Yoko 麻布大学, 獣医学部, 教授 (10318884)
Project Period (FY)	2011 – 2013
Keywords	心拍変動 / 慢性変性性房室弁疾患 / 内科治療 / 犬
Research Abstract	The purpose of this study was to evaluate the effects of various medication used for heart failure on autonomic tone and renin-angiotensin aldosterone system (RAAS) in dogs with chronic valvular heart disease. Five dogs with experimentally induced mitral regurgitation were used. Furosemide, furosemide and pimobendan, combination of furosemide, pimobendan and enaralril, azosemide and placebo were administered in the cross-over design. Variables of heart rate variability were not significantly different among groups. Urine aldosterone creatinine ratio was increased due to furosemide, however, concurrent administration of enalapril did not seem to suppress RAAS activation. Azosemide appeared minimally influence to RAAS.

(1 results)