2013 Fiscal Year Final Research Report
Search of the new anticancer drug material which makes tublin a molecular target from the marine invertebrate as
| Project/Area Number |
23590008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Nagasaki University |
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Principal Investigator |
YAMADA Koji 長崎大学, 医歯(薬)学総合研究科, 准教授 (00253469)
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| Project Period (FY) |
2011 – 2013
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| Keywords | チューブリン / 抗がん剤 / 海洋無脊椎動物 / 棘皮動物 / ナマコ / 海綿動物 / 海洋性細菌 / 海洋性真菌 |
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| Research Abstract |
In this application research, in order to develop the tubulin polymerization and the depolymerization inhibitory substance of the marine invertebrate as a seed compound of a new antineoplastic drug and to separate an active ingredient, the sea invertebrate animal was collected, each animal was processed, and the rough extract was obtained. Furthermore, the extract which has a possibility of having investigated the action on PC12 cell and having affected the tubulin function under nerve growth factor existence about the obtained sample as the first activity testing was found out. The active ingredient was searched about the sponges, sea cucumbers, and the cultivation extract of the bacteria further separated from Bugula neritina, that was accepted to be that activity will be shown. A ceramide, cerebrosides, and diketopiperazine derivatives have been separated. Synthesis of several sorts of analog objects, required in order to evaluate structure activity relationship, was also started.
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Research Products
(17 results)
