Synthesis of highly water-soluble taxol derivatives

2015 Fiscal Year Final Research Report

• Project/Area Number: 23590013
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Oita University
• Principal Investigator: Shimoda Kei 大分大学, 医学部, 准教授 (40284153)
• Co-Investigator(Renkei-kenkyūsha): HAMADA Hiroki 岡山理科大学, 理学部, 教授 (10164914)
• Project Period (FY): 2011-04-28 – 2016-03-31
• Keywords: タキソール / 誘導体 / 合成

Outline of Final Research Achievements

Taxol is a taxane diterpenoid, which shows cytotoxic activity against leukemia cells and inhibitory action against a variety of tumors. It has been recognized as one of the most effective and widely used drugs for the treatment of ovarian, breast, and lung cancers. Despite its effective pharmacological activities, taxol has shortcomings such as low solubility in water. To date, a number of taxol derivatives have been designed and chemically prepared in order to enhance its water-solubility. Saccharide conjugation drastically enhances the water-solubility of aglycones. We synthesized highly water-soluble monosaccharide conjugates of taxol by chemo-enzymatic procedures.

Free Research Field

生物化学