2014 Fiscal Year Final Research Report
Synthetic study toward lomaiviticin A with dimerization of the substrate with flexible structure
| Project/Area Number |
23590018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Musashino University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | ロマイチビチン / 抗生物質 / 抗腫瘍活性 / Michael 反応 / Dieckmann 縮合 / 二量化反応 / 鈴木-宮浦カップリング |
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| Outline of Final Research Achievements |
Toward synthetic study towards antitumor antibiotic lomaiviticin A with dimeric structure, the synthesis of the substrate for the dimerization was explored, which has a structurally flexible 2-aryl cyclohexane derivative before the construction of 5-membered B-ring with suitable solubility for dimerization condition. Substrate for the dimerization was obtained with Suzuki coupling of bromocyclohexenone and Nagata reagent but dimerization at a desired position was not observed. On the other hand, D ring construction from cinnamic acid ester and furanone was achieved by Michael-Dieckmann continuous reaction.
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| Free Research Field |
有機合成化学
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