2014 Fiscal Year Final Research Report
Organochemical Curving Using Catalytic Glycol-Cleavage
| Project/Area Number |
23590024
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Shizuoka Institute of Science and Technology |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | グリコール開裂 / 超原子価ヨウ素 / バナジウム / 酸素酸化 / 環境調和型合成 / 環拡大 / 有機彫刻 / 次亜塩素酸ナトリウム |
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| Outline of Final Research Achievements |
Unfortunately, glycol-cleavage using vanadium-catalyzed aerobic oxidation was not effective for bicyclic glycols because of their steric hindrance. Therefore, we tried to find other environmentally benign glycol-cleavage, and found that hypervalent iodines can react with the bicyclic glycols to cause the glycol-cleavage. Furthermore, we developed glycol-cleavage using sodium hypochlorite catalyzed by iodobenzene. These reactions are effective for the glycol-cleavage of several bicyclic glycols which were synthesized using cyclization.
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| Free Research Field |
化学系薬学
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