2013 Fiscal Year Final Research Report
Research on active compounds from natural resources affecting the differentiation of ES and iPS cells
| Project/Area Number |
23590026
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Meijo University |
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Principal Investigator |
ITO CHIHIRO 名城大学, 薬学部, 准教授 (60193497)
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| Co-Investigator(Renkei-kenkyūsha) |
KOJIMA Nakao 名城大学, 薬学部, 教授 (80333178)
OKAMOTO Yoshinori 名城大学, 薬学部, 助教 (50512323)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 天然資源 / アポトーシス誘導活性 / ヒスタミン放出抑制活性 / がん細胞増殖抑制活性 / 抗酸化活性 / NO産生抑制活性 / ES・iPS細胞分化 |
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| Research Abstract |
Several new compounds were isolated from plant sources together with known compounds. The structures of the new compounds were elucidated by spectroscopic analyses. Several of the isolated compounds exhibited the following useful biological activities: severibuxine, murrayafoline-A, and murrayazolinine significantly suppressed the growth of HL-60 leukemia cells by causing apoptosis; lansamide I, lansiumamide B, and SB-204900 significantly decreased histamine release from RBL-2H3 cells; and lapachol decreased the proliferation rate of hypertrophic scar fibroblasts. Aromatic compounds produced by Eurotium herbariorum from a karebushi were isolated; of these, several benzaldehyde derivatives exhibited high radical scavenging activity. Three carbazolequinone derivatives, synthesized using murrayaquinone-A as a lead compound, inhibited LPS/IFN-induced NO production. No seed compounds affecting the differentiation of ES and iPS cells have been found; however, future research is planned.
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