2013 Fiscal Year Final Research Report
Controls of Solution-mediated Polymorphic Transition and Crystal Growth Rate Utilizing Cyclodextrin Complexation
| Project/Area Number |
23590063
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IOHARA Daisuke 崇城大学, 薬学部, 助教 (40454954)
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| Project Period (FY) |
2011 – 2013
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| Keywords | シクロデキストリン / アセトヘキサミド / アスピリン / 新規結晶多形 / 晶癖 / 溶液媒介性多形転移 / 結晶成長速度 / 包接複合体 |
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| Research Abstract |
The controls of solution-mediated polymorphic transition and crystal growth rate of drugs were conducted, utilizing inclusion complexations with cyclodextrins (CyDs). 1. A new polymorph of acetohexamide (Form VI) was prepared via the formation of a complex with 2-hydroxybutyl-b-cyclodextrin (HB-b-CyD) in aqueous solution. The new crystalline Form VI was highly soluble in water and physically and chemically stable, compared with other polymorphs (Forms I~V). 2. The crystal shape of aspirin was changed from plate to needle crystals, when the crystallizing solvent was changed from water to aqueous 2,6-dimethyl-b-CyD and 2-hydroxybutyl-b-CyD solutions. The results indicate that 2-hydroxybutyl-b-CyD is useful for preparation of metastable forms and control of crystal habit of solid drugs.
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Research Products
(16 results)
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[Journal Article] Improvement of Some Physico- chemical Properties of Arundic Acid, (R)-(-)-2-Propyloctanonic Acid, by Complexation with Hydrophilic Cyclo- dextrins2011
Author(s)
Y. Miyamoto, M. Nakahara, K. Motoyama, T. Ishiguro, Y. Oda, T. Yamanoi, I. Okamoto, A. Yagi, H. Nishimura, F. Hirayama, K. Uekama, H. Arima
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Journal Title
Int. J. Pharm
Volume: 413
Pages: 63-72
DOI
Peer Reviewed
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