2013 Fiscal Year Final Research Report
Elucidation of the physiological function of iNOS degradation system by generating mice in which the SPSB inhibitor is expressed throughout the body
| Project/Area Number |
23590066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
NISHIYA Tadashi 岡山大学, 医歯(薬)学総合研究科, 准教授 (80399831)
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| Project Period (FY) |
2011 – 2013
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| Keywords | SPSB / iNOS / CDC14A / FOG-2 / CTTNBP2 / E3 / ユビキチン化 / 蛋白質分解 |
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| Research Abstract |
We attempted to generate the mice expressing SPSB inhibitor which blocks the association between SPSB and its substrates. Although several F1 mice in which the SPSB inhibitor-expressing gene was introduced were obtained, SPSB inhibitor was not detected in kidneys and livers from these mice. In parallel to this experiment, we identified CDC14A, CTTNBP2 and FOG-2 as novel substrates for SPSB. These substrates are involved in wide variety of physiological functions such as cell cycle control, development of heart and lung, and the dendritic spine formation. Therefore, the inhibition of the degradation of these substrates might cause serious problems for mouse development.
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Research Products
(12 results)
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[Journal Article] Nicotine- and Tar-Free Cigarette Smoke induces cell damage through reactive oxygen species newly generated by PKC-dependent activation of NADPH oxidase2012
Author(s)
Asano H, Horinouchi T, Mai Y, Sawada O, Fujii S, Nishiya T, Minami M, Katayama T, Iwanaga T, Terada K, Miwa S.
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Journal Title
J. Phar macol. Sci
Volume: 118(2)
Pages: 275-287
Peer Reviewed
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[Journal Article] On-off system for PI3-kinase-Akt signaling through S-nitrosylation of PTEN2011
Author(s)
Numajiri N, Takasawa K, Nishiya T, Tanaka H, Ohno K, Hayakawa W, Asada M, Matsuda H, Azumi K, Kamata H, Nakamura T, Hara H, Minami M, Lipton S, Uehara T.
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Journal Title
Proc. Natl. Acad. Sci. U.S.A.
Volume: 108(25)(*Equal contribution)
Pages: 10349-10354
Peer Reviewed
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[Journal Article] NKG2D^+IFN-^+CD8^+T cells are responsible for palladium allergy
Author(s)
Kawano M, Nakayama M, Aoshima Y, Nakamura K, Ono M, Nishiya T, Nakamura S, Takeda Y, Dobashi A, Takahashi A, Endo M, Ito A, Ueda K, Sato N, Higuchi S, Kondo T, Hashimoto S, Watanabe M, Watanabe M, Takahashi T, Sasaki K, Nakamura M, Sasazuki T, Narushima T, Suzuki R, Ogasawara K.
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Journal Title
PLoS One
Volume: 9(2)
Pages: e86810
Peer Reviewed
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