2013 Fiscal Year Final Research Report
The role of collagenolytic matrix metalloproteinase 13 (MMP13) in cancer growth and metastasis.
| Project/Area Number |
23590069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
MASAKI INADA 東京農工大学, 工学(系)研究科(研究院), 准教授 (80401454)
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| Co-Investigator(Kenkyū-buntansha) |
HIRATA Michiko 東京農工大学, 大学院工学研究院, 講師 (40544060)
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| Project Period (FY) |
2011 – 2013
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| Keywords | MMP13 / コラゲナーゼ / 骨 / 軟骨 / 癌 |
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| Research Abstract |
Matrix metalloproteinase 13(MMP13) is key enzyme to cleave collagen, that is the substrate for bone and cartilage. Recently we generated gene deficient mice of MMP13 (MMP13KO). In this investigation, we examined the role of the host produced MMP13 in tumor metastasis and formation in various species of cancer, that was using newly establishing methods of evaluation model of cancer metastasis. These findings indicted that the potential for drug development of MMP13 inhibitors in clinical use.
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Research Products
(23 results)
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[Journal Article] Synthesis of vitamin D(3) derivatives with nitrogen-linked substituents at A-ring C-2 and evaluation of their vitamin D receptor-mediated transcriptional activity2012
Author(s)
Abe J, Nagai Y, Higashikuni R, Iida K, Hirokawa T, Nagai H, Kominato K, Tsuchida T, Hirata M, Inada M, Miyaura C, Nagasawa K
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Journal Title
Org Biomol Chem
Volume: 10(38)
Pages: 7826-7839
DOI
Peer Reviewed
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