2014 Fiscal Year Final Research Report
The physiological roles of the phosphorylation of heterotrimeric G protein signal-dependent RhoGEFs
| Project/Area Number |
23590073
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Gifu University |
|---|
Principal Investigator |
UEDA Hiroshi 岐阜大学, 工学部, 准教授 (50253779)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
AKAO Yukihiro 岐阜大学, 連合創薬医療情報研究科, 教授 (00222505)
|
|---|
| Project Period (FY) |
2011-04-28 – 2015-03-31
|
| Keywords | シグナル伝達 / RhoGEF / Rho / チロシンリン酸化 / キナーゼ |
|---|
| Outline of Final Research Achievements |
Rho family GTPase-specific guanine nucleotide exchange factors of Dbl family regulate a variety of cellular events including cytoskeletal arrangement, signal transduction, and gene expression through activation of Rho family GTPases. FLJ00018/CLG/PLEKHG2 is a guanine nucleotide exchange factor (GEF) for Rho family of small GTPases. In this research project, we have examined the regulation mechanisms of PLEKHG2 by phosphorylation and protein-protein interactions. We showed here that PLEKHG2 interacted with cytosolic actin or phosphoinositide containing PtdIns(4,5)P2, PtdIns(3,4,5)P3 and phosphatidic acid. We showed that PLEKHG2 was phosphorylated by tyrosine kinase Src or EGF receptor signals.
|
| Free Research Field |
生化学
|
