2013 Fiscal Year Final Research Report
Elucidation of roles and their molecular mechanisms on microRNAs specific in esophageal squamous cell carcinoma
| Project/Area Number |
23590076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
TSUCHIYA soken 熊本大学, 生命科学研究部, 講師 (80423002)
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| Project Period (FY) |
2011 – 2013
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| Keywords | microRNA / 食道扁平上皮癌 |
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| Research Abstract |
In the microRNAs whose expressions are changed in human esophageal squamous cell carcinoma as compared with neighboring normal tissues, I found that three microRNAs are involved in cancer cell survival and proliferation and other two microRNAs are involved in cancer cell migration. Furthermore, I comprehensively identified target candidate genes degraded by these microRNA in esophageal squamous cell carcinoma cells. Migration of esophageal squamous cell carcinoma cells was inhibited by each knockdown of two target genes among six target genes of the microRNA, which was most potently inhibited cancer cell migration. As these target genes play important roles on exosytic release, my findings show for the first time the possibility that esophageal squamous cell carcinoma cells accelerate cancer cell migration through exosytic release system.
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