2013 Fiscal Year Final Research Report
Roles epigenetics regulatory factors induced hepatocarcinogenesis in malignant transformation and defense against cancer.
| Project/Area Number |
23590085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
OSADA Shigehiro 名古屋市立大学, 薬学研究科(研究院), 准教授 (40263305)
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| Project Period (FY) |
2011 – 2013
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| Keywords | エピジェネティクス / 細胞がん化 / ヒストン / クロマチン / アセチル化 / メチル化 / ヒストンバリアント |
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| Research Abstract |
Nuclear DNA wraps around histone proteins and is packaged into chromatin. Gene expression is regulated by structure changes of chromatin mediated by the chemical modification of histone, the replacement of canonical histone by histone variants, etc. Dysregulation of histone modification and expression of histone modification enzymes and histone variants leads to diseases including cancer. In this study, we revealed that histone methyltransferase interacted with transcription factors in concerned with carcinogenesis. Further, we found that expression of histone variants was decreased during autophagy, which is involved in promotion and suppression of cancer.
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Research Products
(9 results)
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[Journal Article] Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis2013
Author(s)
Osada, S., Suzuki, S., Yoshimi, C., Matsumoto, M., Shirai, T., Takahashi, S., and Imagawa, M
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Journal Title
Oncol. Rep
Volume: Vol. 30, No. 4
Pages: 1669-1674
Peer Reviewed
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[Journal Article] Inositol phosphate kinase Vip1p interacts with histone chaperone Asf1p in Saccharomyces cerevisiae2012
Author(s)
Osada, S., Kageyama, K., Ohnishi, Y., Nishikawa, J., Nishihara, T., and Imagawa, M
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Journal Title
Mol. Biol. Rep
Volume: Vol. 39, No. 4
Pages: 4989-4996
Peer Reviewed
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