2013 Fiscal Year Final Research Report
Studies on regulation of neutrophilic airway inflammation in severe asthma and chronic obstructive pulmonary disease (COPD)
| Project/Area Number |
23590093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
NABE Takeshi 京都薬科大学, 薬学部, 准教授 (40228078)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUTANI Nobuaki 神戸薬科大学, 薬理学研究室, 講師 (90340447)
FUJII Masanori 京都薬科大学, 薬理学分野, 助教 (40434667)
YASUI Hiroyuki 京都薬科大学, 代謝分析学分野, 教授 (20278443)
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| Research Collaborator |
CHAPLIN David D 米国アラバマ大学バーミングハム校, 微生物学, 教授
WEAVER Casey T 米国アラバマ大学バーミングハム校, 病理学, 教授
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| Project Period (FY) |
2011 – 2013
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| Keywords | 好中球 / 気道炎症 / 喘息 / COPD / 動物モデル / インターロイキン-10 / 制御性T細胞 / 免疫療法 |
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| Research Abstract |
Neutrophilic airway inflammation, a characteristic feature of severe asthma and chronic obstructive pulmonary disease (COPD), was analyzed using murine models, and regulation of the neutrophilic inflammation was evaluated. Unexpectedly, a good COPD model could not be developed even when cigarette smoke was co-administered with an infection factor to mice for a long term. On the other hand, in a murine model of severe asthma, neutrophils were involved in airway obstruction induced several hours after exposure to allergen. It was also found that macrophage-derived chemokines were involved in the neutrophilic airway inflammation. In addition, the neutrophilic inflammation was suppressed by an anti-inflammatory molecule, interleukin (IL)-10, which was endogenously produced. Next, development of a new cellular immunotherapy for asthma was started: Method for induction of IL-10-producing T lymphocytes from spleen cells was developed in vitro.
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[Journal Article] Roles of basophils and mast cells infiltrating the lung by multiple antigen challenges in asthmatic responses of mice2013
Author(s)
Takeshi Nabe, Kouki Matsuya, Kie Akamizu, Marii Fujita, Tomomi Nakagawa, Masayo Shioe, Haruka Kida, Anna Takiguchi, Hiroki Wakamori, Masanori Fujii, Keiichi Ishihara, Satoshi Akiba, Nobuaki Mizutani, Shin Yoshino, David D. Chaplin
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Journal Title
Br. J. Pharmacol
Volume: 169
Pages: 462-476
DOI
Peer Reviewed
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[Journal Article] Regulatory role of antigen-induced interleukin-10, produced by CD4^+ T cells, in airway neutrophilia in a murine model for asthma2012
Author(s)
Takeshi Nabe, Ayumu Ikedo, Fusa Hosokawa, Maki Kishima, Masanori Fujii, Nobuaki Mizutani, Shin Yoshino, Keiichi Ishihara, Satoshi Akiba, David D. Chaplin
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Journal Title
Eur. J. Pharmacol
Volume: 677
Pages: 154-162
DOI
Peer Reviewed
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