2013 Fiscal Year Final Research Report
Role of cytochrome c as a novel signaling molecule by the investigation of LRG knock-out mouse
| Project/Area Number |
23590096
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Osaka University of Pharmaceutical Sciences |
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Principal Investigator |
INOUE Seiji 大阪薬科大学, 薬学部, 准教授 (70183184)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 生体分子 / 蛋白質 / 生理活性 |
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| Research Abstract |
Leucine-rich alpha2-glycoprotein (LRG), one of the serum proteins with unknown function, was found to bind tightly and form complex with the extracellular cytochrome c (Cytc). The positive charges of the residues 8, 13, 72, 73, and 79 of Cytc molecule were important to this binding. A Cytc-LRG complex would function as a danger signal that modulates the immune cells such as bone marrow-derived macrophages to induce G-CSF expression, leading to the neutrophil proliferation in bone marrow.
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