2015 Fiscal Year Final Research Report
Study on host factors involved in Hepatitis C virus life cycle
| Project/Area Number |
23590104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
|
|---|
| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
|
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| Project Period (FY) |
2011-04-28 – 2016-03-31
|
| Keywords | HCV / cell muitants |
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| Outline of Final Research Achievements |
Life cycle of hepatitis C virus (HCV) is still poorly understood. In this project, I was trying to isolate host cell mutants resistant to HCV infection and to identify the defective genes in the mutants. A lot of hepatic cell mutants defective in HCV infection were established, and I found several novel host factors substantially involved in HCV infection. From the results of various analyses using established cell mutants defective in HCV infection, I also confirmed that a tight junction protein occludin is essential for both cell-free HCV entry and cell-to-cell HCV transmission in hepatic cells, and would be therefore a promising anti-HCV drug target.
|
| Free Research Field |
ウイルス学
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