2013 Fiscal Year Final Research Report
Role of a pH-regulating transporter NHE1 as a novel activator of calcineurin
| Project/Area Number |
23590105
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
HISAMITSU Takashi 独立行政法人国立循環器病研究センター, 研究所, 室長 (50327946)
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| Co-Investigator(Kenkyū-buntansha) |
WAKABAYASHI Shigeo 独立行政法人国立循環器病研究センター, 研究所, 部長 (70158583)
NISHITANI Tomoe 独立行政法人国立循環器病研究センター, 研究所, 室長 (50393244)
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| Project Period (FY) |
2011 – 2013
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| Keywords | トランスポーター / カルシニューリン / ｐH / 心肥大 |
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| Research Abstract |
We identified a novel molecular interaction between Na+/H+ exchanger NHE1 and Ca2+-dependent phosphatase calcineurin (CaN), both of which are involved in the progression of cardiac hypertrophy. We sought the significance of this interaction and found that the activated NHE1 amplified the activity of the CaN bound to NHE1, leading to cardiac hypertrophy through activation of a downstream transcription factor NFAT.
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[Journal Article] Na^+/H^+ exchanger 1 is regulated via its lipid-interacting domain, which functions as a molecular switch : A pharmacological approach using indolocarbazole compounds2014
Author(s)
Shimada-Shimizu, N., Hisamitsu, T., Nakamura, T.Y., Hirayama, N., Wakabayashi, S
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Journal Title
Mol. Pharmacol
Volume: 85(1)
Pages: 18-28
DOI
Peer Reviewed
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