2013 Fiscal Year Final Research Report
Analysis of neuroprotective effect of pigment epithelium derived factor
| Project/Area Number |
23590111
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Setsunan University (2012-2013)
Kitasato University (2011) |
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Principal Investigator |
YABE TAKESHI 摂南大学, 薬学部, 教授 (40239835)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Haruki 北里大学, 大学院感染制御科学府, 教授 (60096691)
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| Project Period (FY) |
2011 – 2013
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| Keywords | PEDF / グリア細胞 / グルタミン酸毒性 / 神経細胞死 / 神経新生 |
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| Research Abstract |
Pigment epithelium-derived factor (PEDF) is a 50-kDa secreted glycoprotein and a non-inhibitory member of the serine protease inhibitor (SERPIN) gene family. PEDF is detected in a broad range of human tissues, including almost all brain areas, and has been shown to have strong neuroprotective properties for various types of neurons including cerebellar granule neurons, hippocampal neurons, striatal neurons, retinal neurons and spinal cord motor neurons.These observations raise thepossibility that application of PEDF may be helpful in designing new therapeutic strategies forneurodegenerative diseases. In this study. we tested neuroprptective effect of PEDF in vivo and in vitro.
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