2013 Fiscal Year Final Research Report
Protein tyrosine phosphorylation in the neurovascular unit in cerebrovascular disease and therapeutic strategies
| Project/Area Number |
23590114
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
TAKAGI Norio 東京薬科大学, 薬学部, 教授 (50318193)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳梗塞 / 脳血管 / チロシンリン酸化 |
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| Research Abstract |
This study sought to determine the role of protein tyrosine phosphorylation in the neurovascular unit after stroke. This study demonstrated that MPO-positive cells were increased in the surrounding brain capillaries after stroke, suggesting neutrophil infiltration. This infiltration was inhibited by src inhibitor. The increases in the levels of NOX subunit p67phox and COX-2 were also attenuated by src inhibitor. In addition, this study suggests that the pathophysiological alteration of the blood brain barrier after stroke may be regulated by tyrosine phosphorylation of PDGFR-beta in the pericytes.
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