2013 Fiscal Year Final Research Report
Study of roles of endogenous hydrogen sulfide in stomach with mucosal injury
| Project/Area Number |
23590122
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWABATA Atsufumi 近畿大学, 薬学部, 教授 (20177728)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 硫化水素合成酵素 / 胃癌細胞増殖 / T型カルシウムチャネル / 抗アポトーシス因子 |
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| Research Abstract |
In human gastric cancer-derived AGS cells, our findings suggest that endogenous hydrogen sulfide (H2S) produced by cystathionine-gamma-lyase (CSE), one of H2S-forming enzymes in the mammalian body, accelerates the proliferation of AGS cells. The effects of H2S may be mediated, in part, by increase in function of Cav3.2 T-type calcium channels and upregulation of anti-apoptotic proteins, Bcl-2 and Bcl-xL, via activation of NF-kappaB caused by endogenous H2S. These pathways can be expected to be effective targets for treatment of gastric cancer.
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