2013 Fiscal Year Final Research Report
Development of inhibitors of cancer cell invasion targetting to ADAM17 or transcription factor Snail.
| Project/Area Number |
23590131
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
OKAMOTO Yoshinari 熊本大学, 大学院生命科学研究部(薬), 助教 (20194409)
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| Co-Investigator(Renkei-kenkyūsha) |
OTSUKA Masami 熊本大学, 大学院生命科学研究部, 教授 (40126008)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 癌 / 浸潤・転移 / 亜鉛キレーター / ADAM17 |
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| Research Abstract |
Recently, it has been reported that transcription factor Snail, protease ADAM10 and ADAM17 are participating in invasion and metastasis of cancer cell. The present study aimed at development of specific inhibitors of these proteins.
We are successful to synthesis a new pyridine/cysteamine based zinc chelator equipped with 2-phenylquinoline or butynyl group for recognition of these proteins. Deprotection step of tert-butyl group is ongoing now.
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[Journal Article] Identification of a unique nsaid, fluoro-loxoprofen with gastroprotective activity2012
Author(s)
Shintaro Suemasu, Naoki Yamakawa, Tomoaki Ishihara, Teita Asano, Kayoko Tahara, Ken-ichiro Tanaka, Hirofumi Matsui, Yoshinari Okamoto, Masami Otsuka, Koji Takeuchi, Hidekazu Suzuki, Tohru Mizushima
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Journal Title
Biochemical Pharmacology
Volume: 84 (11)
Pages: 1470-1481
Peer Reviewed
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[Journal Article] Design and synthesis of biotinylated inositol 1,3,4,5-tetrakisphosphate targeting Grp1 pleckstrin homology domain2011
Author(s)
Anraku K, Inoue T, Sugimoto K, Kudo K, Okamoto Y, Morii T, Mori Y, and Otsuka M
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Journal Title
Bioorganic & Medicinal Chemistry
Volume: 19
Pages: 6833-6841
Peer Reviewed
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