2013 Fiscal Year Final Research Report
Synthesis of new compounds inducing potent and selective differentiation from neural stem cells into neurons
| Project/Area Number |
23590136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Shibaura Institute of Technology (2012-2013)
Yokohama College of Pharmacy (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳神経幹細胞 / ニューロン / 分化誘導 / ビタミンK / 誘導体 / 合成 / メナキノン－４ / 再生医療 |
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| Research Abstract |
We synthesized new compounds, which have selective differentiation activity from neuronal progenitor cells into neurons in vitro. The result of the assay exhibited vitamin K analogues introduced m-methylphenyl group at the omega-terminal position had the most potent activity, which was twice as much as control. This finding indicated that it will be possible to obtain much more potent compounds with modification of vitamin K. Now we are going to investigate the functional mechanism of the compounds.
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[Journal Article] Menadione (vitamin K_3) is not only a catabolic product of oral phylloquinone (vitamin K_1) in the intestine but also a circulating precursor of tissue menaqunone-4 (vitamin K_2) in rats2013
Author(s)
HIROTA, Y.; TSUGAWA, N.; NAKAGAWA, K.; SUHARA, Y.; UCHINO, Y.; TAKEUCHI, A.; SAWADA, N.; KAMAO, M.; WADA, A.; OKITSU, T, OKANO, T
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Journal Title
J. Biol. Chem
Volume: 288(46)
Pages: 33071-33080
DOI
Peer Reviewed
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[Journal Article] Functional and structural analysis of influenza virus neuraminidase N_3 offers further insight into the mechanisms of oseltamivir resistance2013
Author(s)
LI, Q.; QI, J.; WU, Y.; KIYOTA, H.; TANAKA, K.; SUHARA, Y.; OHRUI, H.; SUZUKI, Y.; VAVRICKA, C. J.; GAO, G. F
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Journal Title
J. Virol
Volume: 87 (16)
Pages: 10016-10024
DOI
Peer Reviewed
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[Journal Article] Structure-Activity Relationship of Novel Menaquinone-4 Analogues : Modification of the Side Chain Affects their Biological Activities2012
Author(s)
SUHARA,Y.; HANADA, N.; OKITSU, T.; SAKAI, M.; WATANABE, M.; NAKAGAWA, K.; WADA, A.; TAKEDA, K.; TAKAHASHI, K.; TOKIWA, H.; OKANO, T
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Journal Title
J. Med. Chem
Volume: 55
Pages: 1553-1558
DOI
Peer Reviewed
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